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A randomized, placebo-controlled crossover trial in patients with binge-eating disorder and bulimia nervosa

About the Course:

To date, only two medications have been approved by the Food and Drug Administration (FDA) for eating disorders: lisdexamfetamine for binge-eating disorder (BED) and fluoxetine for bulimia nervosa (BN). While these two drugs are effective, what are options for patients who cannot tolerate these medications or do not find them helpful? This article describes the results of the first study to rigorously investigate a promising new treatment option for BED and BN: phentermine-topiramate extended release (PHEN/TPM-ER). In addition to helping readers make sense of the study’s major findings, this article will also explain the rationale behind this dual combination drugs including potential mechanisms of action. Finally, this article will help readers stay up-to-date on the latest treatment options for patients who do not have optimal responses to existing FDA-approved medications.

Publication Date:

International Journal of Eating Disorders November 23, 2019

Course Material Authors

Debra L. Safer MD

Dr. Debra L. Safer specializes in the treatment of eating and weight disorders. She has practiced psychiatry for more than 15 years. Dr. Safer is the Co-Director of the Stanford Adult Eating and Weight Disorders Program. Her research and clinical work in eating disorders and obesity focus on improving patient outcomes by developing and conducting clinical intervention trials to establish evidence-based treatments. She has co-authored multiple peer-reviewed articles, books, and book chapters, and presented her work both nationally and internationally.

Sarah Adler PsyD

Dr. Adler is passionate about the intersection between behavioral health and technology to increase access to care. She is currently an attending Psychologist in the Eating Disorder and Weight Control Clinic and specializes in both research and clinical care for patients with disordered eating behaviors. Dr. Adler is the Author of The DBT Solution for Binge and Emotional Eating, which was originally written and tested for her doctoral dissertation. Dr. Adler currently teaches and supervises students and post-doctoral fellows in evidence based treatments.

Shebani Sethi Dalai MD, MS

Dr. Sethi Dalai is an Attending Psychiatrist in the Department of Psychiatry and Behavioral Sciences and Director of Metabolic Psychiatry. She has specialized training and expertise in obesity medicine and adult eating disorders. Dr. Sethi Dalai’s approach to psychiatric treatment incorporates principles of obesity medicine, metabolic health, and nutrition. She is a co-investigator on a clinical trial testing an FDA approved obesity medication for binge-eating disorder and bulimia nervosa at Stanford University funded by SPARK.

Recommended For:

Counselors, marriage and family therapists, psychologists and social workers. This course is appropriate for intermediate levels of knowledge. The content is at an intermediate level.

Course Objectives:

  1. Explain the rationale for repurposing phentermine-topiramate extended release (PHEN/TPM-ER) for treating individuals with binge eating disorder and bulimia nervosa

  2. Describe the effects on binge eating and other key outcomes when PHEN/TPM-ER was compared to placebo in a randomized crossover study.

  3. Identify future research directions to follow-up on these preliminary positive findings regarding the safety and efficacious use of PHEN/TPM-ER for binge eating disorder and bulimia nervosa

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Course Material

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Course Number 102721
1 credit hour
  • Online Article
Exam Fee: $6.97No exam fee with a Plus or Unlimited membership package!
4 out of 5
9 members have taken this course