102000: A Placebo-Controlled Pilot Study of the Novel Opioid Receptor Antagonist ALKS-33 in Binge Eating Disorder

Volume 46, Issue 3

About the Course:

To assess preliminarily the effectiveness of a novel opioid antagonist, ALKS-33, in binge eating disorder (BED).

Journal/Publisher:

Wiley Interscience Journal, International Journal of Eating Disorders

Publication Date:

April 2013

Authors

Susan L. McElroy, MD; Anna I. Guerdjikova, PhD, LISW; Thomas J. Blom, MS; Scott J. Crow, MD; Asli Memisoglu, PhD; Bernard L. Silverman, MD; Elliot W. Ehrich, MD

Recommended For:

This course is recommended for professionals who seek knowledge about the pharmacotherapy of binge eating disorder.

Course Objectives:

  1. Describe the role endogenous opioids may play in binge eating behavior.

  2. Describe the rational for use of opioid antagonists in BED.

  3. Explain that in a small phase II, proof of concept study in 62 outpatients with BED, the novel opioid antagonist ALK-33 was not superior to placebo on any measure of eating pathology or body weight.

Exam Questions

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